66 A COMPUTATIONAL PHENOTYPE FOR CARBAPENEM-RESISTANT ENTEROBACTERALES AND EXTENDED-SPECTRUM BETA-LACTAMASE-PRODUCING ENTEROBACTERALES INFECTIONS TO SUPPORT ELECTRONIC HEALTH RECORD-BASED SURVEILLANCE EFFORTS

66 A computational phenotype for carbapenem-resistant Enterobacterales and extended-spectrum beta-lactamase-producing Enterobacterales infections to support electronic health record-based surveillance efforts

Objectives/Goals: The objective of this project was to develop electronic health record-based algorithms, or computational phenotypes, for carbapenem-resistant Enterobacterales (CRE) and extended-spectrum beta-lactamase-producing Enterobacterales (ESBL) infections based on public health surveillance case definitions.Methods/Study Population: We ana

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Structural plasticity in mesencephalic dopaminergic neurons produced by drugs of abuse: critical role of BDNF and dopamine.

Mesencephalic dopaminergic neurons were suggested to be a critical physiopathology substrate for addiction disorders.Among neuroadaptive processes to addictive drugs, structural plasticity has attracted attention.While structural plasticity occurs at both pre- and post-synaptic levels in the mesolimbic dopaminergic system, the present review focuse

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